Xinlin Yang · 杨忻霖

Electrochemical biosensors,
one monolayer at a time.

Undergraduate researcher at Xi'an Jiaotong–Liverpool University (XJTLU), working on mixed self-assembled monolayers (SAMs), electrochemical impedance spectroscopy (EIS), and screen-printed-electrode (SPE) platforms for label-free biosensing. Applying for PhD / MPhil positions in electrochemistry & bioelectronics (2027 Fall entry).

BSc Applied Chemistry, XJTLU Class of 2027 Tangshan, China

About

I'm a third-year undergraduate in Applied Chemistry at XJTLU, where I work in Dr. Qiuchen Dong's research group on electrochemical biosensors. My current focus is the MCH-ol dilution strategy for mixed SAMs: by co-adsorbing a short hydroxyl-terminated diluent with the capturing thiol (11-MUA), I can suppress 3D cluster growth and force a uniform 2D monolayer — a 5× improvement in inter-electrode reproducibility on Au working electrodes, with 6× faster SAM formation.

Previously I developed a dual-modal EIS + OD600 method for E. coli K-12 on screen-printed electrodes, and I am the co-founder and R&D lead of AquaSense, a start-up translating that sensor into a field-deployable water-quality platform.

Outside the lab: football (Arsenal, patiently), long walks, cooking, and a growing collection of headphone recommendations I'm happy to argue about.

Research

Mixed SAM-Modified Electrodes for Improved Cortisol Immunosensor Reproducibility

Jun 2026 – Jul 2026

Summer Undergraduate Research Fellow (SURF #2) · XJTLU · Supervisor: Dr. Qiuchen Dong

  • Designed a controlled single-variable experiment comparing mixed SAM (11-MUA + 6-MCH-ol, 1:10 mol ratio, 12 h) vs. single-component MPA SAM (72 h) on Au bulk working electrodes — cleanly isolating the MCH-ol dilution effect from MUA-density confounds.
  • Independently performed all wet-lab work, EIS characterization (0.1 Hz–100 kHz, +0.17 V DC, Randles + CPE fitting), and 8-concentration × 3-replicate cortisol calibration (0.1 ng/mL – 100 µg/mL) across 4 independent electrodes.
  • Built an end-to-end analysis pipeline (xlsx → Python → visualization → PDF) and transparently reported a worst-case R² = 0.69 alongside the best-case R² = 0.984 — keeping calibration-rule choices auditable.
  • Methodology adapted from T. Ji et al., Talanta 280 (2024) 126776.
Key result: 5× lower Rct standard deviation at the LOD edge (450 → 91 Ω at 0.1 ng/mL), 6× faster SAM formation (12 h vs. 72 h), inter-electrode RSD ≈ 24%. First-author methodology manuscript in preparation (target: Talanta / Biosensors and Bioelectronics).

EIS + Optical Dual-Modal Detection of E. coli K-12 on Screen-Printed Electrodes

Jun 2025 – Sep 2025

Summer Undergraduate Research Fellowship (SURF #1) · XJTLU · Supervisor: Dr. Qiuchen Dong · Project No. SURF-2025-0494

  • Cultured E. coli K-12 in LB medium; built a semi-quantitative dual-modal cross-validation by simultaneously acquiring EIS (1 Hz–100 kHz, 10 mV, 20 mM K3[Fe(CN)6] / 1 M KNO3) and OD600.
  • Functionalised Au SPEs (alumina polish → electrochemical cleaning → MPA SAM in 75:25 EtOH:H2O, overnight) with anti-E. coli antibody via EDC/NHS coupling (4 µg/mL, 2 h) and 1% BSA blocking.
  • Operated Autolab PGSTAT302N; extracted charge-transfer resistance Rct via Randles equivalent-circuit fitting as the primary quantitative metric.
  • Screened 6 candidate variables for inter-batch drift and identified the polishing-to-SAM interval as the dominant factor — reducing cross-batch RSD from 30%+ to 12%.
Awarded: Excellent Poster Award, SURF 2025 Poster Session. Methodology manuscript in preparation (target: Talanta / Biosensors and Bioelectronics).

Experience

Co-founder · Bio-engineer · R&D Lead — AquaSense

Sep 2025 – Present

XJTLU Start-up Incubator

  • Translating the SURF #1 EIS sensor into a field-deployable E. coli water-quality platform; owning the anti-E. coli antibody immobilisation on gold working electrodes and the wet-lab LOD performance.
  • Drove PoC-to-product engineering: pushing lab-scale single-point EIS toward a deployable prototype while balancing electrochemical stability, iteration cadence, and cross-functional resource priorities.
  • Represented the team at the 15th "Challenge Cup" China College Students' Entrepreneurship Plan Competition (provincial round) — led technical Q&A and the roadshow pitch.

Research Fellow — Dr. Qiuchen Dong's Research Group

Jun 2025 – Sep 2025

Department of Chemistry, XJTLU

  • Led a 3-person wet-lab team; designed a shared Google-Sheet booking system with 7 AM priority shifts to resolve Autolab potentiostat contention, raising equipment utilisation from 60% to 90%.
  • Diagnosed and resolved a critical RSD rebound (12% → 28%) two days before the mid-term presentation by tracing it to a contaminated EDC/NHS batch and switching back to a known-good lot.
  • Owned the full electrode-modification workflow and Randles-circuit EIS analysis; produced a complete dataset and draft manuscript.

Education

BSc Applied Chemistry

Sep 2023 – Jul 2027

Xi'an Jiaotong–Liverpool University (XJTLU) · Suzhou, China

Selected Year 1–2 modules:

Inorganic Applications of Group Theory Intermediate Organic Chemistry The Biology of Microbes Preparative Chem. Synthesis & Charact. Lab. Techniques Intermediate Inorganic Chemistry Further Key Skills in Chemistry Measurements in Chemistry Introductory Spectroscopy Intermediate Physical Chemistry Analytical Chemistry

Skills & Tools

Wet-lab
EIS (Randles + CPE fitting) · SAM self-assembly (mixed MUA / MCH-ol, MPA) · Screen-printed electrode (SPE) functionalisation · EDC/NHS antibody coupling · Alumina polishing · Cyclic voltammetry
Instruments
Autolab PGSTAT302N · Metrohm NOVA · ZView (impedance fitting) · Standard wet-lab glassware
Programming
Python pandas matplotlib
Writing & Tools
LaTeX (Overleaf) · Zotero · Google Workspace · Excel
Languages
English (fluent — listening / speaking / reading / writing) · Chinese (native)
Interests
Travelling · Football · Music · Cooking

Contact

I'm actively looking for PhD / MPhil opportunities starting Fall 2027 in electrochemistry, bioelectronics, or SAM-based biosensing. If you're working on something I might fit into, please get in touch.